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Ebf4 | Transcription factor COE4; Seems to weakly activate transcription. Binds an Olf-1 consensus site in vitro; Belongs to the COE family. (599 aa) | ||||
Dtx1 | E3 ubiquitin-protein ligase DTX1; Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Mainly acts as a positive regulator of Notch, but it also acts as a negative regulator, depending on the developmental and cell context. Mediates the antineural activity of Notch, possibly by inhibiting the transcriptional activation mediated by MATCH1. Involved in neurogenesis, lymphogenesis and myogenesis, and may also be involved in MZB (Marginal zone B) cell differentiation. Promotes B-cell development [...] (627 aa) |