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Utf1 | Undifferentiated embryonic cell transcription factor 1; Acts as a transcriptional coactivator of ATF2. (339 aa) | ||||
Suz12 | Polycomb protein Suz12; Polycomb group (PcG) protein. Component of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene. The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems (By similarity). Genes repressed by the PRC2/EED- EZH2 complex include HOXA7, HOXB6 and HOXC8. Belongs to the VEFS (VRN2-EMF2-FIS2-SU(Z)12) family. (741 aa) |