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trr | Histone-lysine N-methyltransferase trr; Histone methyltransferase that acts as a coactivator for the ecdysone receptor during development. Specifically trimethylates 'Lys- 4' of histone H3, a specific tag for epigenetic transcriptional activation. Recruited by EcR in an ecdysone-dependent manner causing H3 'Lys-4' trimethylation at ecdysone-inducible promoters, leading to activate expression. Plays a central role in the developing compound eye, during the progression of the morphogenetic furrow and in post- furrow differentiation of the retinal epithelium, notably by activating express [...] (2431 aa) | ||||
Hmg-2 | High mobility group protein 2 (Hmg-2) encodes a member of the non-histone chromosomal high-mobility group protein family. These proteins associate with with chromatin and are ubiquitously distributed in the nucleus of eukaryotic cells. The product of Hmg-2 binds to DNA in a non-sequence specific fashion to induce structural changes in DNA that include bending and unwinding that in turn, promote DNA flexibility. (376 aa) |