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ph-d | Polyhomeotic distal (ph-d) encodes a stoichiometric subunit of the Polycomb repressive complex 1. The complex silences a variety of genes involved in developmental patterning, regulation of cell proliferation, differentiation and polarity. Together with its paralog ph-p, ph-d functions as a tumor suppressor gene. (1537 aa) | ||||
Sid | Stress induced DNase (Sid) encodes a protein belonging to an evolutionarily conserved enzyme family that degrades both single and double stranded nucleic acids. Sid expression is highly induced by bacterial infection and oxidative stress. Its apparent role is to protect from the toxic effects of excess DNA/RNA released by a vigorous immune response. (370 aa) |