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ph-d | Polyhomeotic distal (ph-d) encodes a stoichiometric subunit of the Polycomb repressive complex 1. The complex silences a variety of genes involved in developmental patterning, regulation of cell proliferation, differentiation and polarity. Together with its paralog ph-p, ph-d functions as a tumor suppressor gene. (1537 aa) | ||||
comm | Protein commissureless 1; Commissureless (comm) product regulates the cell surface localization of Robo axon guidance receptors by intercepting them in the ER/Golgi during exocytosis or removing them from the surface by endocytosis. comm is required for formation of the CNS axon scaffold and synaptogenesis. (370 aa) |