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N | Processed neurogenic locus Notch protein; Essential signaling protein which has a major role in many developmental processes. Functions as a receptor for membrane-bound ligands Delta and Serrate to regulate cell-fate determination. Upon ligand activation, and releasing from the cell membrane, the Notch intracellular domain (NICD) forms a transcriptional activator complex with Su(H) (Suppressor of hairless) and activates genes of the E(spl) complex. Regulates oogenesis, the differentiation of the ectoderm and the development of the central and peripheral nervous system, eye, wing disk, [...] (2703 aa) | ||||
UbcE2H | Ubiquitin conjugating enzyme E2H (UbcE2H)encodes an E2 enzyme involved in protein ubiquitylation. It is involved in response to viral infection; Belongs to the ubiquitin-conjugating enzyme family. (183 aa) |