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mago | Protein mago nashi; Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs. Involved in exon definition of genes containing long introns, including the rolled/MAPK gene. The mago-tsu heterodimer interacts with the EJC key regulator Pym leading to EJC disassembly in the cytoplasm. Has a role in oskar mRNA localization to the posterior pole of the developing oocyte, and may also be involved in polarization of the oocyte microtubule cytoskeleton. (147 aa) | ||||
step | Steppke, isoform C; Steppke (step) encodes a member of the cytohesin family of guanine nucleotide exchange factors, which regulate small GTPases of the ADP-ribosylation factor (ARF) family. It contributes to multiple signaling pathways, such as Egfr, MAPK, PI3K and insulin signaling. It is involved in wing and eye development, germ cell segregation and cell growth. (727 aa) |