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pita | Pita, isoform A; Pita (pita) encodes an architectural chromatin protein essential for embryonic development that organizes open chromatin in the regulatory regions (predominantly promoters). pita product functions include enhancer blocking, support of distant interactions, protection from spreading of repressed chromatin and recruitment of transcription factors. (683 aa) | ||||
Smurf | E3 ubiquitin-protein ligase Smurf1; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Down-regulates Dpp signaling after gastrulation by promoting MAD ubiquitination and subsequent degradation. (1061 aa) |