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Ssrp | FACT complex subunit Ssrp1; Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment o [...] (723 aa) | ||||
d4 | D4, isoform A; Histone acetyltransferase activity; histone binding; zinc ion binding. It is involved in the biological process described with: negative regulation of transcription, DNA-templated; positive regulation of transcription by RNA polymerase II; nervous system development. (497 aa) |