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dre4 | FACT complex subunit spt16; Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment o [...] (1122 aa) | ||||
BigH1 | Histone H1 variant BigH1 (BigH1) encodes a germline linker histone H1 variant that is retained in the early embryo until cellularization. It is required for gametogenesis and to maintain silencing of the zygotic genome during early embryogenesis. (353 aa) |