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The following proteins in
Drosophila melanogaster
appear to match your input.
Please review the list, then click 'Continue' to proceed.
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⤓ Mapping
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1) '7227.FBpp0073433':
Upf1 - Regulator of nonsense transcripts 1 homolog; RNA-dependent helicase and ATPase required for nonsense- mediated decay (NMD) of mRNAs containing premature stop codons. Is recruited to mRNAs upon translation termination and undergoes a cycle of phosphorylation and dephosphorylation; its phosphorylation appears to be a key step in NMD. The formation of an Upf1-Upf2-Upf3 surveillance complex is believed to activate NMD (By similarity).
[a.k.a. FBgn0030354, Upf1-PA, Upf1-PB,
7227.FBpp0073433
]
2) 'Mondo':
Mondo
- Mlx interactor alpha;
Mondo
(
Mondo
) encodes a basic helix-loop-helix-leucine zipper transcription factor involved in lipid and carbohydrate metabolism. Together with its binding partner encoded by bigmax, it controls sugar-dependent gene expression, including activation of genes involved in lipogenesis.
Mondo
mutants are intolerant to dietary sugars and have impaired muscle function.
bigmax - GM14426p; Bigmax (bigmax) encodes a basic helix-loop-helix-leucine zipper transcription factor. Together with its binding partner encoded by
Mondo
, the product of bigmax is involved in sugar-dependent gene regulation. It is involved in transcriptional control of many metabolic pathways, including glycolysis, de novo lipogenesis and the pentose phosphate pathway. Loss of bigmax function produces dietary sugar intolerance.
[a.k.a. FBgn0039509, bigmax-PA, Mlx]
sug - Zinc finger protein GLIS2 homolog; Sugarbabe (sug) encodes a transcription factor that regulates the expression of insulin-like peptides and genes involved in lipid and carbohydrate metabolism. It is a direct target of the sugar sensor encoded by
Mondo
and its expression is also promoted by the product of daw; Belongs to the GLI C2H2-type zinc-finger protein family.
[a.k.a. FBgn0033782, sug-PA, sug-PB]