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Su(z)12 | Polycomb protein Su(z)12; Polycomb group (PcG) protein. While PcG proteins are generally required to maintain the transcriptionally repressive state of homeotic genes throughout development, this protein is specifically required during the first 6 hours of embryogenesis to establish the repressed state. Component of the Esc/E(z) complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene. The Esc/E(z) complex is necessary but not sufficient for the repression of homeotic target genes, suggesting that [...] (900 aa) | ||||
Nab2 | Nuclear polyadenosine RNA-binding 2 (Nab2) encodes a zinc-finger polyadenosine RNA binding protein that is expressed widely in many cell types but required specifically within the developing nervous system for proper behavior and axonogenesis. The product of Nab2 in supports in neurons short term memory and development of the brain mushroom bodies. (1004 aa) |