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D | Dichaete (D) encodes an HMG-domain protein and member of the Sox family of transcription factors. Its roles include hindgut development, embryonic segmentation, and nervous system development. (382 aa) | ||||
Mad1 | Mitotic arrest-deficient 1 (Mad1) encodes a conserved, essential component of the spindle checkpoint. During mitosis, it is recruited to unattached kinetochores, where it binds the product of mad2 and promotes the assembly of the products of mad2 and fzy into the mitotic checkpoint complex. During interphase, Mad1 is intranuclear, bound to the product of mad2, and associated primarily with the nuclear pore complex. (730 aa) |