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CTCF | GH14774p; CTCF (CTCF) encodes a ubiquitous transcription factor that binds to insulators and domain boundaries. It mediates insulator function and blocks enhancers by binding to the product of Cp190. It contributes to long-range chromatin interaction, organizes chromatin domain boundaries and coordinates nuclear architecture. (818 aa) | ||||
ft | Cadherin-related tumor suppressor; Involved in regulation of planar cell polarity in the compound eye where it is required for correct specification of the R3 and R4 photoreceptor cells by regulating Fz activity in the R3/R4 precursor cells. This is likely to occur through creation of an ft gradient so that the equatorial R3/R4 precursor cell has a higher level of ft function than its polar neighbor. Also required for planar cell polarity of wing hairs. Mediates heterophilic cell adhesion in vitro and is required to stabilize ds on the cell surface. Involved in regulation of eye imagin [...] (5147 aa) |