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Elba3 | Early boundary activity protein 3; The heterotrimeric Elba complex is required for chromatin domain boundary function during early embryogenesis. It binds to a 8-bp sequence 5'-CCAATAAG-3' in the Fab-7 insulator or boundary element in the bithorax complex and contributes to its insulator or boundary activity. Elba3 lacks DNA-binding activity and plays the role of an adapter protein, bringing Elba1 and 2 together, thereby establishing a complex that recognizes the asymmetric sequence motif through the BEN domains of Elba1 and 2. (379 aa) | ||||
Npc1b | NPC intracellular cholesterol transporter 1 homolog 1b; Important for cholesterol absorption at the midgut epithelium. Acts only in the early steps of sterol absorption, prior to Npc1a-dependent intracellular sterol trafficking. Belongs to the patched family. (1254 aa) |