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insv | Protein insensitive; Can act as both a transcriptional repressor and corepressor. Represses the expression of genes involved in neural development and preferentially binds palindromic sequence 5'-CCAATTGG-3' to mediate transcriptional repression. Acts as a corepressor for suppressor of hairless (Su(H)) and inhibits Notch signaling during peripheral nervous system development. (376 aa) | ||||
Ptpmeg | Protein tyrosine phosphatase Meg (Ptpmeg) encodes a tyrosine phosphatase that interacts with the product of Eps-15. It negatively regulates border cell migration during oogenesis. It also inhibits the EGFR/Ras/mitogen-activated protein kinase signaling pathway during wing morphogenesis; Belongs to the protein-tyrosine phosphatase family. Non- receptor class subfamily. (974 aa) |