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insv | Protein insensitive; Can act as both a transcriptional repressor and corepressor. Represses the expression of genes involved in neural development and preferentially binds palindromic sequence 5'-CCAATTGG-3' to mediate transcriptional repression. Acts as a corepressor for suppressor of hairless (Su(H)) and inhibits Notch signaling during peripheral nervous system development. (376 aa) | ||||
miple2 | Midkine and pleiotrophin 2 (miple2) encodes a small secreted protein that binds Heparin and is closely related at the amino acid sequence to the product of miple1. It is strongly expressed in the developing endoderm. (282 aa) |