Your Input: | |||||
Utx | Utx histone demethylase (Utx) encodes a Jumonji C containing protein that catalyzes the removal of methyl groups from Histone H3 lysine 27. Together with the products of trr and Lpt, it is thought to regulate chromatin structure at transcriptional enhancers. (1136 aa) | ||||
calypso | Ubiquitin carboxyl-terminal hydrolase calypso; Polycomb group (PcG) protein. Catalytic component of the PR- DUB complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-118' (H2AK118ub1). Does not deubiquitinate monoubiquitinated histone H2B. Required to maintain the transcriptionally repressive state of homeotic genes throughout development. The PR-DUB complex has weak or no activity toward 'Lys- 48'- and 'Lys-63'-linked polyubiquitin chains. Belongs to the peptidase C12 family. BAP1 subfamily. (471 aa) |