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Su(H) | Suppressor of hairless protein; Transcriptional regulator that plays a central role in Notch signaling, a signaling pathway involved in cell-cell communication that regulates a broad spectrum of cell-fate determinations. Binds directly the 5'-GTGRGAR-3' DNA consensus sequence, which is present in the regulatory region of several genes. Acts as a transcriptional repressor when it is not associated with Notch proteins. When associated with some Notch protein, it acts as a transcriptional activator that activates transcription of Notch target genes. Required for transcription of Sim. Spec [...] (594 aa) | ||||
Cyp18a1 | Cytochrome P450-18a1 (Cyp18a1) encodes a P450 enzyme that inactivates the hormone 20 hydroxy ecdysone through addition of an OH group to the 26 carbon of the hormone molecule. It is expressed in many larval tissues. Cyp18a1 mutants result in prepupal lethality due to improper activation kinetics of the transcription factor encoded by ftz-f1. (538 aa) |