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Su(H) | Suppressor of hairless protein; Transcriptional regulator that plays a central role in Notch signaling, a signaling pathway involved in cell-cell communication that regulates a broad spectrum of cell-fate determinations. Binds directly the 5'-GTGRGAR-3' DNA consensus sequence, which is present in the regulatory region of several genes. Acts as a transcriptional repressor when it is not associated with Notch proteins. When associated with some Notch protein, it acts as a transcriptional activator that activates transcription of Notch target genes. Required for transcription of Sim. Spec [...] (594 aa) | ||||
Mcr | Macroglobulin complement-related (Mcr) encodes a transmembrane protein of the conserved thioester-containing protein (TEP) superfamily including macroglobulins and complement proteins. It is a core component of septate junctions, which provide an essential paracellular barrier to epithelia. (1760 aa) |