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Su(H) | Suppressor of hairless protein; Transcriptional regulator that plays a central role in Notch signaling, a signaling pathway involved in cell-cell communication that regulates a broad spectrum of cell-fate determinations. Binds directly the 5'-GTGRGAR-3' DNA consensus sequence, which is present in the regulatory region of several genes. Acts as a transcriptional repressor when it is not associated with Notch proteins. When associated with some Notch protein, it acts as a transcriptional activator that activates transcription of Notch target genes. Required for transcription of Sim. Spec [...] (594 aa) | ||||
kappaB-Ras | NF-kappa-B inhibitor-interacting Ras-like protein; Atypical Ras-like protein that may act as a regulator of NF- kappa-B activity, possibly by preventing the degradation of NF-kappa-B inhibitor cactus; Belongs to the small GTPase superfamily. Ras family. KappaB-Ras subfamily. (201 aa) |