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esg | Protein escargot; Transcription factor that can both stimulate and repress transcription. Binds to the consensus DNA sequence 5'-A/GCAGGTG-3'. Regulates cell motility and adhesion during tracheal morphogenesis by stimulating transcription of the DE-cadherin gene shg at branch tips, thereby promoting tracheal tube fusion. Maintains diploidy in imaginal cells by inhibiting the transcription of genes required for endoreplication. Required for development of the genital disk and acts as an intrinsic determinant of wing cell fate. The somatic protein is required for maintenance of male germ [...] (470 aa) | ||||
Msh6 | Probable DNA mismatch repair protein Msh6; Msh6 (Msh6) encodes a heterodimer with the product of spel1 to detect base-base mismatches and small insertion/deletion loops. It then recruits the rest of the mismatch repair machinery. (1190 aa) |