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esg | Protein escargot; Transcription factor that can both stimulate and repress transcription. Binds to the consensus DNA sequence 5'-A/GCAGGTG-3'. Regulates cell motility and adhesion during tracheal morphogenesis by stimulating transcription of the DE-cadherin gene shg at branch tips, thereby promoting tracheal tube fusion. Maintains diploidy in imaginal cells by inhibiting the transcription of genes required for endoreplication. Required for development of the genital disk and acts as an intrinsic determinant of wing cell fate. The somatic protein is required for maintenance of male germ [...] (470 aa) | ||||
Kdm4A | Lysine (K)-specific demethylase 4A (Kdm4A) encodes a histone lysine demethylase that catalyzes removal of methyl groups using alpha-ketoglutarate as a cofactor. It demethylates H3K36me3 and is implicated in the demethylation of H3K9me3 and H3K56me3. Its roles include transcription, DNA repair, and heterochromatin silencing. (495 aa) |