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hth | Homeobox protein homothorax; All isoforms are required for patterning of the embryonic cuticle. Acts with exd to delimit the eye field and prevent inappropriate eye development. Isoforms that carry the homeodomain are required for proper localization of chordotonal organs within the peripheral nervous system and antennal identity; required to activate antennal-specific genes, such as sal and to repress the leg-like expression of dac. Necessary for the nuclear localization of the essential HOX cofactor, extradenticle (exd). Both necessary and sufficient for inner photoreceptors to adopt [...] (487 aa) | ||||
Socs44A | Suppressor of Cytokine Signaling at 44A (Socs44A) encodes a protein that promotes the degradation of interacting proteins by recruiting Cullin/Elongin ubiquitin ligase complexes. It activity negatively regulates JAK/STAT signaling and positively impacts RTK signaling in a context specific manner, which can impact developmental patterning. (342 aa) |