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Sce | E3 ubiquitin-protein ligase RING1; E3 ubiquitin-protein ligase that mediates monoubiquitination of 'Lys-118' of histone H2A, thereby playing a central role in histone code and gene regulation. H2A 'Lys-118' ubiquitination gives a specific tag for epigenetic transcriptional repression. Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development. PcG [...] (435 aa) | ||||
Rad1 | DNA repair protein Rad1; Radiation insensitive 1 (Rad1) encodes a protein that together with proteins encoded by Rad9 and Hus1-like form the 9-1-1 checkpoint protein complex. This complex plays a central role in the DNA damage-induced checkpoint response. (274 aa) |