Your Input: | |||||
Sce | E3 ubiquitin-protein ligase RING1; E3 ubiquitin-protein ligase that mediates monoubiquitination of 'Lys-118' of histone H2A, thereby playing a central role in histone code and gene regulation. H2A 'Lys-118' ubiquitination gives a specific tag for epigenetic transcriptional repression. Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development. PcG [...] (435 aa) | ||||
bsh | Brain-specific homeobox protein; DNA binding protein that function as transcriptional activator (By similarity). May play a role in the determination and function of cell types in the brain; Belongs to the distal-less homeobox family. (429 aa) |