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Sce | E3 ubiquitin-protein ligase RING1; E3 ubiquitin-protein ligase that mediates monoubiquitination of 'Lys-118' of histone H2A, thereby playing a central role in histone code and gene regulation. H2A 'Lys-118' ubiquitination gives a specific tag for epigenetic transcriptional repression. Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development. PcG [...] (435 aa) | ||||
Nhe3 | Sodium/hydrogen exchanger; Sodium:proton antiporter activity; potassium:proton antiporter activity. It is involved in the biological process described with: regulation of intracellular pH; potassium ion transmembrane transport; sodium ion import across plasma membrane; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (711 aa) |