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tll | Protein tailless; Orphan receptor that binds DNA as a monomer to hormone response elements (HRE) containing an extended core motif half-site sequence 5'-AAGTCA-3' in which the 5' flanking nucleotides participate in determining receptor specificity. This receptor binds to the consensus sequence [AG][AG]AAGTCAA. Plays a key role in the establishment of non-metameric domains at the anterior and posterior poles of the embryo. It may also play a role in the nervous system. The maternal terminal pathway activates the tll gene in the termini; TLL activity then represses segmentation and activ [...] (452 aa) | ||||
nesd | Protein nessun dorma; Required during male meiosis for completion of spermatocyte cytokinesis and possibly also required in female germline cells. Also involved in ring canal formation in male and female germline cells. Not essential for cleavage furrow ingression but is required for contractile ring stability and the attachment of the furrowing membrane to the actomyosin ring in late telophase. Displays high binding affinity for beta-galactosides. (602 aa) |