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eve | Segmentation protein even-skipped; May play a role in determining neuronal identity. May be directly involved in specifying identity of individual neurons. Pair- rule protein required for segmentation; involved in transforming the broad, spatial, aperiodic expression patterns of the gap genes into a system of precise periodic expression patterns of the pair-rule and segmentary polarity genes; Belongs to the even-skipped homeobox family. (376 aa) | ||||
Hs2st | Heparan sulfate 2-O-sulfotransferase (Hs2st) encodes a heparan sulfate modifying enzyme, which transfers a sulfate group to 2-O position of glucuronic or iduronic acid residues of heparan sulfate. Loss of Hs2st function eliminates 2-O sulfation, but increases 6-O sulfation performed by the product of Hs6st. Simultaneous elimination of Hs6st and Hs2st functions disrupts FGF, Wg and Dpp signaling pathways. (349 aa) |