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Kdm4A | Lysine (K)-specific demethylase 4A (Kdm4A) encodes a histone lysine demethylase that catalyzes removal of methyl groups using alpha-ketoglutarate as a cofactor. It demethylates H3K36me3 and is implicated in the demethylation of H3K9me3 and H3K56me3. Its roles include transcription, DNA repair, and heterochromatin silencing. (495 aa) | ||||
Usp47 | Ubiquitin carboxyl-terminal hydrolase 47; Ubiquitin-specific protease that deubiquitinates target proteins to regulate different cellular and developmental pathways. Functions downstream of Dsor1/MEK to positively regulate the Ras/MAPK signaling pathway. Likely to modulate the pathway during various cellular and developmental processes including rl/MAPK activation by the receptors InR, Egfr and sevenless/sev. Functions in the post-translational stabilization of rl/MAPK levels in a mechanism that is independent of rl activity and opposes the activity of the E2 enzyme Unc6 and the putati [...] (1556 aa) |