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pho | Polycomb protein PHO; Polycomb group (PcG) protein that binds to the 5'- CNGCCATNNNNG-3' sequence found in the regulatory regions of many genes. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development. They probably act via the methylation of histones, rendering chromatin heritably changed in its expressibility. Probably targets the Esc/E(z) complex to DNA. Necessary but no [...] (520 aa) | ||||
Diedel | Protein Diedel; Cytokine which promotes survival following infection by Sindbis virus by suppressing the immune deficiency pathway. Following infection by the enteropathogenic bacteria E.carotovora limits intestinal stem cells proliferation. When secreted from muscle or adipose tissue, can attenuate age-related intestinal tissue degeneration by inhibiting apoptosis ; Belongs to the Diedel family. (115 aa) |