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pho | Polycomb protein PHO; Polycomb group (PcG) protein that binds to the 5'- CNGCCATNNNNG-3' sequence found in the regulatory regions of many genes. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development. They probably act via the methylation of histones, rendering chromatin heritably changed in its expressibility. Probably targets the Esc/E(z) complex to DNA. Necessary but no [...] (520 aa) | ||||
Hsp22 | Heat shock protein 22 (Hsp22) encodes a molecular chaperone that is encoded in the nucleus and targeted to the mitochondrial matrix. Hsp22 expression is dramatically increased during aging, and both Hsp22 mutation and over-expression are reported to modulate adult life span and stress resistance. (174 aa) |