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pho | Polycomb protein PHO; Polycomb group (PcG) protein that binds to the 5'- CNGCCATNNNNG-3' sequence found in the regulatory regions of many genes. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development. They probably act via the methylation of histones, rendering chromatin heritably changed in its expressibility. Probably targets the Esc/E(z) complex to DNA. Necessary but no [...] (520 aa) | ||||
wac | Augmin complex subunit wac; As part of the augmin complex, plays a role in centrosome- independent generation of spindle microtubules. The complex is required for mitotic spindle assembly through its involvement in localizing gamma-tubulin to spindle microtubules. wac is dispensable for somatic mitosis and for assembly of spindle microtubules in oocytes during female meiosis but is required during female meiosis for chromosome alignment and segregation. It is required for microtubule assembly near spindle poles in oocytes. It is also required for acentrosomal microtubule nucleation and [...] (163 aa) |