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Ada2b | Transcriptional adapter 2B; Required for the function of some acidic activation domains, which activate transcription from a distant site. Binds double-stranded DNA. Binds dinucleosomes, probably at the linker region between neighboring nucleosomes. Plays a role in chromatin remodeling. (555 aa) | ||||
wgn | Tumor necrosis factor receptor superfamily member wengen; Receptor for egr. Involved in induction of apoptosis by triggering JNK signaling. Mediates the tumor suppressor activity of egr which eliminates oncogenic cells from epithelia, thereby maintaining epithelial integrity. Following UV-induced epidermal damage, binds to egr released from apoptotic epidermal cells and plays a role in development of thermal allodynia, a responsiveness to subthreshold thermal stimuli which are not normally perceived as noxious. Together with Moe, involved in control of axon targeting of R8 and R2-R5 ph [...] (343 aa) |