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Dsp1 | High mobility group protein DSP1; Binds preferentially single-stranded DNA and unwinds double- stranded DNA. (397 aa) | ||||
Notum | Palmitoleoyl-protein carboxylesterase NOTUM; Carboxylesterase that acts as a key negative regulator of the Wnt signaling pathway by specifically mediating depalmitoleoylation of WNT proteins. Serine palmitoleoylation of WNT proteins is required for efficient binding to frizzled receptors. Also acts as a regulator of long-range activity of Hedgehog (hh), possibly by regulating the switch between low and high level hh pathway signaling. Belongs to the pectinacetylesterase family. Notum subfamily. (671 aa) |