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Sfmbt | Polycomb protein Sfmbt; Polycomb group (PcG) protein that binds to the Polycomb response elements (PREs) found in the regulatory regions of many genes. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development. They probably act via the methylation of histones, rendering chromatin heritably changed in its expressibility. Necessary but not sufficient to recruit a functional Pc [...] (1243 aa) | ||||
IntS3 | Integrator complex subunit 3; Component of the Integrator complex, a complex involved in the transcription of small nuclear RNAs (snRNA) and their 3'-box- dependent processing. However this subunit is not essential for the 3'-end processing of the snRNA U7 and the spliceosomal snRNAs U1, U2, U4 and U5. Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the INT complex (By similarity). (1068 aa) |