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The following proteins in
Drosophila melanogaster
appear to match your input.
Please review the list, then click 'Continue' to proceed.
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1) '7227.FBpp0288697':
yki - Transcriptional coactivator yorkie; Transcriptional coactivator which is the critical downstream regulatory target in the Hippo/SWH (Sav/Wts/Hpo) signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein Hippo (Hpo), in complex with its regulatory protein Salvador (Sav), phosphorylates and activates Warts (Wts) in complex with its regulatory protein Mats, which in turn phosphorylates and inactivates the Yorkie (Yki) oncoprotein. The Hippo/ [...]
[a.k.a. FBgn0034970, yki-PH, yki-PD,
7227.FBpp0288697
]
2) '7227.FBpp0070347':
trr - Histone-lysine N-methyltransferase trr; Histone methyltransferase that acts as a coactivator for the ecdysone receptor during development. Specifically trimethylates 'Lys- 4' of histone H3, a specific tag for epigenetic transcriptional activation. Recruited by EcR in an ecdysone-dependent manner causing H3 'Lys-4' trimethylation at ecdysone-inducible promoters, leading to activate expression. Plays a central role in the developing compound eye, during the progression of the morphogenetic furrow and in post- furrow differentiation of the retinal epithelium, notably by activating express [...]
[a.k.a. FBgn0023518, trr-PC, trr-PD,
7227.FBpp0070347
]