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foxo | Forkhead box protein O; Transcription factor involved in the regulation of the insulin signaling pathway. Consistently activates both the downstream target Thord4EBP and the feedback control target InR. Involved in negative regulation of the cell cycle, modulating cell growth and proliferation. In response to cellular stresses, such as nutrient deprivation or increased levels of reactive oxygen species, foxo is activated and inhibits growth through the action of target genes such as Thor. Foxo activated in the adult fat body can regulate lifespan in adults; an insulin peptide itself m [...] (622 aa) | ||||
CG1894 | Histone acetyltransferase activity; histone binding; H4 histone acetyltransferase activity. It is involved in the biological process described with: histone acetylation; positive regulation of transcription by RNA polymerase II; negative regulation of transcription, DNA-templated; Belongs to the MYST (SAS/MOZ) family. (421 aa) |