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Su(var)3-9 | Histone-lysine N-methyltransferase Su(var)3-9; Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3 using monomethylated H3 'Lys-9' as substrate. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting Su(var)205/HP1 to methylated histones. Mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric regions. Involved in heterochromatic gene silencing including the modification of position-effect-variegation. Belongs to the cl [...] (635 aa) | ||||
Toll-7 | Toll-like receptor 7; Toll-related receptor which binds to the neurotrophins NT1 and spz5. Essential for antiviral autophagy, it detects and binds to the vesicular stomatitis virus (vsv) following infection. This role is likely to be independent of the canonical Toll, immune deficiency, and JAK-STAT signaling pathways. Functions in olfactory circuit assembly by promoting synaptic partner matching between olfactory receptor neurons (ORN) axons and projection neurons (PN) dendrites partners in the antennal lobe. Function in the Va1d ORNs is necessary and sufficient for correct targeting [...] (1446 aa) |