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E(bx) | Nucleosome-remodeling factor subunit NURF301; Histone-binding component of NURF (nucleosome remodeling factor), a complex which catalyzes ATP-dependent nucleosome sliding and facilitates transcription of chromatin. Specifically recognizes H3 tails trimethylated on 'Lys-4' (H3K4me3), which mark transcription start sites of virtually all active genes. Required for homeotic gene expression, proper larval blood cell development, normal male X chromosome morphology, ecdysteroid signaling and metamorphosis. Belongs to the BPTF family. (2761 aa) | ||||
Wee1 | Wee1-like protein kinase; Wee1 kinase (Wee1) encodes a tyrosine kinase required for triggering entry into mitosis. The activity of the Wee1 product contributes to spindle assembly and alignment and separation of the chromosomes; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. WEE1 subfamily. (609 aa) |