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Mad | Mothers against dpp (Mad) encodes the primary transcription factor that mediates cellular response to the BMP like ligands encoded by dpp, scw and gbb. Upon phosphorylation by either the products of sax or tkv (type I BMP receptors), it forms a complex with the product of Med and translocates to the nucleus where, together with cofactors, it regulates expression of BMP response target genes; Belongs to the dwarfin/SMAD family. (525 aa) | ||||
ifc | Sphingolipid delta-4 desaturase activity. It is involved in the biological process described with: spermatogenesis; spindle assembly involved in male meiosis; ceramide biosynthetic process; Belongs to the fatty acid desaturase type 1 family. DEGS subfamily. (321 aa) |