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Mad | Mothers against dpp (Mad) encodes the primary transcription factor that mediates cellular response to the BMP like ligands encoded by dpp, scw and gbb. Upon phosphorylation by either the products of sax or tkv (type I BMP receptors), it forms a complex with the product of Med and translocates to the nucleus where, together with cofactors, it regulates expression of BMP response target genes; Belongs to the dwarfin/SMAD family. (525 aa) | ||||
NFAT | NFAT nuclear factor, isoform B; DNA-binding transcription factor activity; chromatin binding; transcription factor binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding. It is involved in the biological process described with: positive regulation of transcription by RNA polymerase II; negative regulation of synaptic vesicle exocytosis; response to salt stress. (1457 aa) |