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Mad | Mothers against dpp (Mad) encodes the primary transcription factor that mediates cellular response to the BMP like ligands encoded by dpp, scw and gbb. Upon phosphorylation by either the products of sax or tkv (type I BMP receptors), it forms a complex with the product of Med and translocates to the nucleus where, together with cofactors, it regulates expression of BMP response target genes; Belongs to the dwarfin/SMAD family. (525 aa) | ||||
d | Dachs, isoform E; Dachs (d) encodes a myosin family protein that participates in Dachsous-Fat signaling, which polarizes its localization. It influences planar cell polarity, partly through interaction with the product of pk, and growth, through interaction with the product of wts; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1426 aa) |