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Mad | Mothers against dpp (Mad) encodes the primary transcription factor that mediates cellular response to the BMP like ligands encoded by dpp, scw and gbb. Upon phosphorylation by either the products of sax or tkv (type I BMP receptors), it forms a complex with the product of Med and translocates to the nucleus where, together with cofactors, it regulates expression of BMP response target genes; Belongs to the dwarfin/SMAD family. (525 aa) | ||||
ss | Spineless, isoform C; Spineless (ss) encodes a protein that plays a key role in defining the distal regions of the antenna and the leg. Its stochastic expression in R7 photoreceptors also controls the expression of color Rhodopsins (the product of Rh4 vs. the product of Rh3) in the two subsets of ommatidia. (1015 aa) |