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Mad | Mothers against dpp (Mad) encodes the primary transcription factor that mediates cellular response to the BMP like ligands encoded by dpp, scw and gbb. Upon phosphorylation by either the products of sax or tkv (type I BMP receptors), it forms a complex with the product of Med and translocates to the nucleus where, together with cofactors, it regulates expression of BMP response target genes; Belongs to the dwarfin/SMAD family. (525 aa) | ||||
asrij | OCIA domain-containing protein 1; Asrij (asrij) encodes a conserved ovarian carcinoma immunoreactive antigen domain-containing endosomal protein that maintains stemness. It positively regulates JAK/STAT signalling and negatively regulates the Notch pathway. It interacts with the GTP-bound form of the product of Arf79F to regulate hematopoiesis and immunity; Belongs to the OCIAD1 family. (258 aa) |