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Trl | Transcription factor GAGA; Transcriptional activator that functions by regulating chromatin structure. Overcomes the repressive effects of chromatin by promoting the open chromatin conformation in promoter gene regions, thereby allowing access to other transcription factors. Binds to DNA Polycomb response elements (PREs) at the bithorax complex and to the proximal region of the engrailed promoter, and positively regulates transcription of many genes including homeotic ones. Binds to the DNA sequence (GA)n, with optimal binding to the pentamer 5'-GAGAG-3'. Binds DNA as an oligomer. May [...] (623 aa) | ||||
Usp30 | Ubiquitin carboxyl-terminal hydrolase 30 homolog; Deubiquitinating enzyme that acts as a key inhibitor of mitophagy by counteracting the action of parkin (park). Belongs to the peptidase C19 family. (558 aa) |