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Trl | Transcription factor GAGA; Transcriptional activator that functions by regulating chromatin structure. Overcomes the repressive effects of chromatin by promoting the open chromatin conformation in promoter gene regions, thereby allowing access to other transcription factors. Binds to DNA Polycomb response elements (PREs) at the bithorax complex and to the proximal region of the engrailed promoter, and positively regulates transcription of many genes including homeotic ones. Binds to the DNA sequence (GA)n, with optimal binding to the pentamer 5'-GAGAG-3'. Binds DNA as an oligomer. May [...] (623 aa) | ||||
Reck | Reversion-inducing-cysteine-rich protein with kazal motifs, isoform A; Endopeptidase inhibitor activity; metalloendopeptidase inhibitor activity. It is involved in the biological process described with: extracellular matrix organization; negative regulation of metalloendopeptidase activity; negative regulation of endopeptidase activity; regulation of canonical Wnt signaling pathway; vasculature development. (1071 aa) |