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E(z) | Histone-lysine N-methyltransferase E(z); Polycomb group (PcG) protein. Catalytic subunit of the Esc/E(z) complex, which methylates 'Lys-9' and 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. While PcG proteins are generally required to maintain the transcriptionally repressive state of homeotic genes throughout development, this protein is specifically required during the first 6 hours of embryogenesis to establish the repressed state. The Esc/E(z) complex is necessary but not sufficient for the repression of homeotic target genes, suggesting [...] (765 aa) | ||||
Hr39 | Hormone receptor-like in 39 (Hr39) encodes a nuclear hormone receptor protein in subfamily 5. It is a master regulator of female reproductive gland development from the bipotential genital disc, and in adults is required for reproductive gland secretion, ovulation and additional functions. (808 aa) |