Your Input: | |||||
LYL1 | Protein lyl-1; LYL1 basic helix-loop-helix family member. (280 aa) | ||||
ARRDC1 | Arrestin domain-containing protein 1; Functions as an adapter recruiting ubiquitin-protein ligases to their specific substrates. Through an ubiquitination-dependent mechanism plays for instance a role in the incorporation of SLC11A2 into extracellular vesicles. More generally, plays a role in the extracellular transport of proteins between cells through the release in the extracellular space of microvesicles. By participating to the ITCH-mediated ubiquitination and subsequent degradation of NOTCH1, negatively regulates the NOTCH signaling pathway ; Belongs to the arrestin family. (433 aa) |