Your Input: | |||||
SETDB1 | Histone-lysine N-methyltransferase SETDB1; Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. H3 'Lys-9' trimethylation is coordinated with DNA methylation. Required for HUSH- mediated heterochromatin formation and gene silencing. Forms a complex with MBD1 and ATF7IP that represse [...] (1291 aa) | ||||
ZFP69 | Zinc finger protein 69 homolog; Putative transcription factor that appears to regulate lipid metabolism; Belongs to the krueppel C2H2-type zinc-finger protein family. (526 aa) |